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Home > Research, Discovery & Progress > Program Overview
Three cores support ProstateSPORE research and development projects:
- Administration
- Biostatistics
- Tissue
Contact:
Jill Miller, Administrator
Phone: (734) 998-6761
jsmiller@umich.edu
Core Director: Kenneth J. Pienta, M.D.
Core Co-Director: Kathleen A. Cooney, M.D.
Core Co-Director: James E. Montie, M.D.
The University of Michigan Comprehensive Cancer Center (UMCCC) Prostate SPORE administrative core is responsible for leadership, guidance and management. The administrative core oversees all aspects and performs numerous duties across the expansive scope of the SPORE. These duties are:
- Provide scientific leadership to the SPORE investigators
- Direct the translational components of the overall SPORE program
- Function as the coordinating unit for SPORE activities and information
- Oversee and administer all budgetary issues and finances
- Maintain UMCCC Prostate SPORE web page
- Provide administrative framework for all projects, research development, career development, and cores
- Administer the yearly competition for pilot projects and seed grants
- Apply cost effectiveness and quality control factors
- Facilitate interactions between the SPORE and the University
- Facilitate interactions between the SPORE and other SPOREs and the NCI
- Communicate with NCI program staff and coordinate submission of required reports
- Convene and provide administrative support for meetings
- Provide oversight for the recruitment of women and minorities
- Assure compliance with regulations regarding animals in research
- Coordinate quality assurance between tissue banks and databases
- Coordinate and organize community outreach efforts
Kenneth J. Pienta, MD, director of urologic oncology for the University of Michigan Comprehensive Cancer Center continues to serve as principal investigator of the Administrative Core. Kathleen Cooney, MD, serves as the co-principal investigator of the Administrative Core. Dr. Cooney oversees all of the developmental programs as well as the Biostatistics and Tissue Cores. James Montie, M.D., serves as a co-principal investigator responsible for the translational science of the SPORE and directs the new Clinical Applications Core. Ms. Jill Miller has filled the role as SPORE administrator since 1998 and will continue in this role. She has demonstrated her ability to administer this large research program in an efficient manner. This core provides the framework to support the success and mission of the UMCCC SPORE as a cohesive group of investigators committed to the development of translational research in prostate cancer.
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Contact:
Core Director: Jeremy M.G. Taylor, Ph.D.
Phone: (734) 936-9580
jmgt@umich.edu
The goal of the Biostatistics Core is to collaborate with SPORE investigators and other core resource scientists to enhance the quality of the research undertaken in the University of Michigan Prostate SPORE. The Core personnel have been chosen because of their expertise in relevant areas of Biostatistics and because of their experience and knowledge of prostate cancer.
Biostatistics Core personnel will collaborate with every one of the six proposed projects, will interact with the other cores and also will expect to interact with all funded development awards, and thus this core is crucially important to the SPORE. Personnel from the core will interact with the investigators in all stages of the research, beginning with the formulation of the research question, through the experimental design stage and data collection stage, to data analysis and interpretation, to the writing of reports and dissemination of results. Two areas where biostatistical expertise is indispensable are in experimental design and data analysis. It will be apparent from this proposal that Core personnel have played a significant role in designing the proposed experiments and in planning the data analysis. The Specific Aims of the Core are:
- Assist investigators in the design of clinical and laboratory experiments
- Assist investigators in the analysis and interpretation of data from clinical and laboratory experiments and in writing of scientific manuscripts relaying prostate cancer SPORE results to the scientific community
- Undertake translational biostatistics research to develop methodology relevant to prostate cancer.
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Related Publications:
- Cooney KA, Strawderman MS, Wojno KJ, Doerr KM, Taylor A, Alcser KH, Heeringa SG, Taylor JMG, Wei JT, Montie JE, Schottenfeld D: Age-specific distribution of serum prostate-specific antigen in a community-based study of African American men. Urology 57(1): 91-96, 2001.
- Cooper, C., Walsh, M., Taylor, J.M.G., Hayasaka, S., Pienta, K.: "Preferential Adhesion of Prostate Cancer Cells to Bone is Mediated by Binding to Bone Marrow Endothelial Cells as Compared to Extracellular Matrix Components in Vitro." Clinical Cancer Research 6:4839-4847, 2000.
- Ghosh, D., Chinnaiyan, A.: "Mixture Modelling of Gene Expression Data from Microarray Experiments." Bioinformatics, 18: 275-286, 2002.
- Law, J., Taylor, J.M.G., Sandler, H.: "The Joint Modeling of a Longitudinal Disease Progression Marker and The Failure Time Process in the Presence of Cure". Biostatistics, in press 2002.
- Rubin, M., Dunn, R., Strawderman, M., Pienta, K.: "Tissue Microarray Sampling Strategy for Prostate Cancer Biomarker Analysis." American Journal of Surgical Pathology, 26(3): 312-9, 2002.
- Taylor, J.M.G., Cooper, K., Wei, J., Raghunathan, T., Heeringa, S.: "Multiple Imputation to Correct for Selection Bias in a Urological Symptoms Survey of African-American Men," American J. Epidemiology, 156: (8) 774-782, 2002.
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Contact:
Core Director: Arul Chinnaiyan, M.D., Ph.D.
Core Technical Director: Javed Siddiqui, M.S.
Phone: 734-764-3732
Email: siddiqui@umich.edu
Please note:
Tissue Core Recharge Rates
All investigators requesting services and/or specimens from the Prostate SPORE Tissue Core must first
complete a Specimen Request Form (see below) to initiate the request. Services to
investigators external to the University of Michigan are limited to tissue-related services only.
All requests, internal or external, are subject to approval by the Tissue Usage Committee.
Investigators may be charged for these services. The Tissue Core Recharge Rates above are for UM investigators. For more information, please contact the Core Technical Director, Javed Siddiqui (contact information above).
Specimen Request Form
The goal of Prostate SPORE Tissue Core is to collect biological material with associated clinical information to facilitate translational research. The Tissue Core places patient confidentiality and clinical care as a top priority. As a coordinated effort between pathology, urology, and SPORE researchers, the Core has a developed a unified bioinformatics infrastucture (designated "Profiler") that provides researchers a wide range of annotated samples. To date, detailed information exists on over 1400 radical prostatectomy patients operated on at the University of Michigan between 1994-present. The specific goals of the Tissue Core include:
- Protection of patient welfare. The highest priority is given to assure that no research protocol compromises pathology diagnosis or tumor staging. Patient confidentiality is maintained through use of an IRB-approved database protocol
- Acquisition and processing of prostate tissues for research. The Core assures that the widest range of prostate tissues and derived biomolecules (i.e., protein, DNA and RNA) are available from several established and new sources. These include benign prostate tissue from patients without any known prostatic disease (cystoprostatectomy specimens and transplant donor prostates), clinically localized prostate cancer (U of M), metastatic hormone naïve prostate cancer (Ulm, Germany), and metastatic hormone refractory prostate cancer (Rapid Autopsy Program).
- Maintenance of clinical and pathology data with links to molecular studies. The Tissue/Informatics Core will continue to expand the detailed clinical and pathology database conforming to the National Cancer Institute's Common Data Elements (CDE) guidelines, permitting queries between molecular findings and clinically relevant outcomes.
- High quality pathologic review of prostate tissues. Expert pathologists assure uniform review of prostate tissue samples.
- Pathology consultation for the purpose of designing translational research projects. This service focuses on determining the types of tissues and amount required for the successful completion of the projects.
- Quality assessment of prostate tissues and clinical data. The Tissue Core staff regularly evaluates frozen and formalin fixed tissues for adequacy.
- Development of technology appropriate for pathology based translational research.
In this renewal, new biostatistical strategies are presented to evaluate biomarkers using tissue microarrays. Technologies such as quantitative real time PCR and laser capture microdissection protocols will be refined. In summary, the Tissue Core will provide SPORE investigators with a wealth of carefully annotated samples for translational research, while maintaining the highest level of clinical care.
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Related Publications:
- Kuefer R, Varambally S, Zhou M, Lucas PC, Loeffler M, Wolter H, Mattfeldt T, Hautmann RE, Gschwend JE, Barrette TR, Dunn RL, Chinnaiyan AM, Rubin MA.
alpha-Methylacyl-CoA Racemase: Expression Levels of this Novel Cancer Biomarker Depend on Tumor Differentiation. Am J Pathol. 2002 Sep;161(3):841-8.
- Varambally S., Dhanasekaran, S.M., Barrette, T.R., Sanda, M.G., Ghosh, D., Pienta, K.J., Sewalt, R.G.A.B., Otte, A.P., Rubin, M.A., Chinnaiyan, A.M. (2002). The Polycomb Group Protein EZH2 is Involved in Prostate Cancer Progression. Nature, 419, 624 - 629.
- Hollenbeck, B.K., et al., Whole mounted radical prostatectomy specimens do not increase detection of adverse pathological features. J Urol, 2000. 164(5): p. 1583-6.
- Bova, G.S., et al., "Web-based tissue microarray image data analysis: initial validation testing through prostate cancer Gleason grading." Hum Pathol, 2001. 32(4): p. 417-27.
- Rubin, M.A., et al., "Rapid ('warm') autopsy study for procurement of metastatic prostate cancer." Clin Cancer Res, 2000. 6(3): p. 1038-45.
- Rubin, M.A., et al., "Should a Gleason score be assigned to a minute focus of carcinoma on prostate biopsy?" Am J Surg Pathol, 2000. 24(12): p. 1634-40.
- Zhou, M., et al., "Lack of Association between Prostate Carcinoma Nuclear Grading and Prostate Specific Antigen Recurrence Following Radical Prostatectomy." J Urol, 2001. In press.
- Chay, C.H., Cooper, C.R., Gendernalik, J.D., Dhanasekaran, S.M., Chinnaiyan, A.M., Rubin, M.A., Pienta, K.J. A functional thrombin receptor (PAR1) is expressed on bone-derived prostate cancer cell lines. Urology, In press, 2002.
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Please Note:
Applications for Pilot Projects and Seed grants are now available!
( the applications open as word documents)
Download the Seed Grant application
Download the Pilot Project application
  
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