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U-M CCC - Michigan Oncology Journal Fall 2000

Advancements in Clinical and Basic Science Research from the University of Michigan Comprehensive Cancer Center

Editor
Laurence H. Baker, D.O.
Deputy Director and
Director for Clinical Research
U-M Comprehensive Cancer Center

Assistant Editor
Maria McKinney White
Director
Marketing and Public Relations

Michigan Oncology Journal
Copyright ©2000
University of Michigan
Comprehensive Cancer Center

From the Editor

Since the early 1970s, the incidence rates for non-Hodgkin's lymphoma (NHL) have nearly doubled. During the last decade, however, the rate of increase appeared to slow and may actually be tapering off. Current estimates indicate that there will be 54,900 new cases this year and more than 26,000 deaths. Clearly, more effective, less toxic therapies are needed.

Mark Kaminski, M.D., and his colleagues at the Cancer Center are playing a pivotal role in strengthening our arsenal against non-Hodgkin's lymphoma. Dr. Kaminski's clinical research has received widespread scientific and media attention in recent years. His promising work involves the use of the mouse monoclonal anti-CD20 antibody tagged with the radioisotope I-131. In this issue of the Michigan Oncology Journal, Dr. Kaminski brings us up to speed on the state of antibody therapy for non-Hodgkin's lymphoma.

Drs. Jakubowiak and Erba focus on staging and treatment issues related to intermediate- and high-grade NHL. They review the latest clinical trials underway for this group of lymphomas.

Dr. Okada addresses characteristics and treatments for the new small lymphocytic lymphomas, including mantle cell, marginal-zone, extranodal MALT, nodal marginal-zone b-cell, and splenic marginal-zone/splenic with villous lymphocytes lymphomas.

Finally, Dr. Ross offers an update on the revised European-American Classification of Lymphoid Neoplasms (REAL) classification, its benefits and shortcomings, and what's next on the horizon for classification of this disease group.

As always, thank you for your interest in our program. We welcome your feedback.

Laurence H. Baker, D.O.

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