Project 1
Kuklev DV, Hankin JA, Uhlson CL, Hong YH, Murphy RC, Smith WL.
Major urinary metabolites of 6-keto-prostaglandin F2α in mice.
J Lipid Res. 2013 May 3. PMID: 23644380. PMCID: None.

Neilson AP, Djuric Z, Ren J, Jiang J, Reuven S, Lager C, Hong YH, Sen A, Smith WL, Brenner DE.
Effect of cyclooxygenase genotype and dietary fish oil on colonic eicosanoids in mice.
J Nutri Cancer. 2012;64(1):163-72. Epub 2011 Dec 9. PMID: 22149144. PMCID: 3410550.

Project 2
Nie S, Lo A, Zhu J, Wu J, Ruffin MT, Lubman DM.
An Isobaric Protein-Level Labeling Strategy for Serum Glycoprotein Quantification Analysis by LC-MS/MS.
Anal Chem. 2013 May 2. PMID: 23638883 . PMCID: None.

Lin, Z., D. Simeone, M. Anderson, R. Brand, X. Xie, K. Shedden, M. Ruffin, D. Lubman.
A Mass Spectrometric Assay for Analysis of Haptoglobin Fucosylation in Pancreatic Cancer.
Journal of Proteome Research 2011, 2011 May 6;10(5):2602-11. Epub 2011 Mar 31. NIHMSID#284125 PMCID: PMC3090531[Available on 2012/5/6]

Project 3
Parsels, L.A., Qian, Y, Tanska, D.M., et al.
Assessment of Chk1 phosphorylation as a pharmacodynamic biomarker of Chk1 inhibition
Clin Cancer Res.2011 Jun 1;17(11):3706-15
Epub 2011 Apr 11. PMCID: PMC3107893[Available on 2012/6/1]

Vance, Sean, Erqi Liu, Lili Zhao, Joshua D Parsels, Leslie A Parsels, Jeffery L Brown, Jonathan Maybaum, Theodore S Lawrence, and Meredith A Morgan.
"Selective Radiosensitization of P53 Mutant Pancreatic Cancer Cells by Combined Inhibition of Chk1 and PARP1."
Cell Cycle 10, no. 24 (2011): doi:10.4161/cc.10.24.18661. PMID: 22134241. PMCID: PMC3272262.

Venkatesha, Venkatasubbaiah A, Leslie A Parsels, Joshua D Parsels, Lili Zhao, Sonya D Zabludoff, Diane M Simeone, Jonathan Maybaum, Theodore S Lawrence, and Meredith A Morgan.
"Sensitization of Pancreatic Cancer Stem Cells to Gemcitabine by Chk1 Inhibition."
Neoplasia (New York, N.Y.) 14, no. 6 (2012): 519-25. PMID: 22787433. PMCID: PMC3394194.

Zhao, L., Morgan, M.A., Parsels, L.A., et al.
Bayesian Hierarchical Changepoint Methods in Modeling the Tumor Growth Profiles in Xenograft Experiments.
Clin Cancer Res 17, no. 5 (2011): doi:10.1158/1078-0432.CCR-10-1935. PMID: 21131555. PMCID: PMC3048927.

Project 4
Kim EJ, Ben-Josef E, Herman J, Bekaii-Saab T, Dawson L, Griffith K, Francis IR, Greenson J, Simeone DM, Lawrence T, Laheru D, Wolfgang CL, Williams T, Bloomston M, Moore M, Wei A, Zalupski MM.
A Multi-institutional phase II study of neoadjuvant gemcitabine and oxaliplatin with radiation therapy in patients with pancreatic cancer.
Cancer (in press).

Kumar-Sinha C, Wei I, Simeone DM.
Emerging frontiers in pancreatic cancer research: elaboration of key genes, cells, and the extracellular milieu.
Curr Opin Gastroenterol. 2012 Sep;28(5):516-22. PMID: 22759592. PMCID: None Posted.

Wang L, Yang H, Palmbos PL, Ney G, Detzler TA, Coleman D, Leflein J, Davis M, Zhang M, Tang W, Hicks JK, Helchowski CM, Prasad J, Lawrence T, Xu L, Yu X, Canman CE, Ljungman M, Simeone DM.
Phosphorylation of ATDC via ATM/MAPKAP Kinase 2 signaling mediates radioresistance of pancreatic cancer cells
(under review).

Career Development

Publication - Hyeun Joong Yoon, Tae Hyun Kim, Zhuo Zhang, Trinh M. Pham, Costanza Paoletti, Jules Lin, Nithya Ramnath, Max S. Wicha, Daniel F. Hayes, Diane M. Simeone, and Sunitha Nagrath,
"Sensitive Planar Capture of Circulating Tumor Cells by Self Assembled Graphene Oxide Based Nano-Arms", (in review, Nature Nanotechnology).

Kothari V, Wei I, Shankar S, Kalyana-Sundaram S, Wang L, Ma LW, Vats P, Grasso CS, Robinson DR, Wu YM, Cao X, Simeone DM, Chinnaiyan AM, Kumar-Sinha C.
Outlier kinase expression by RNA sequencing as targets for precision therapy.
Cancer Discov. 2013 Mar;3(3):280-93. doi: 10.1158/2159-8290.CD-12-0336. Epub 2013 Feb 5. PMID: 23384775. PMCID: PMC3597439.

Kumar-Sinha C, Wei I, Simeone DM.
Emerging frontiers in pancreatic cancer research: elaboration of key genes, cells, and the extracellular milieu.
Curr Opin Gastroenterol. 2012 Sep;28(5):516-22. PMID: 22759592. PMCID: None.

Poster Presentation

Anton K, Rheaume R, Gallaghar S, Aman D, Gerlach S, Tuck M, Normolle D, Sen A, Brenner D.
Early Detection Research Network and SPORE: Resource Sharing to Promote Cost-effective and Standardized Data Models and Data Management Systems for GI Cancer Research.
Cancer Biomarker Bioinformatics Workshop. California Institute of Technology, April 29- May 1, 2013.

Manuscripts in Preparation

Edgar Ben-Josef, William F. Regine, Ross Abrams, Meredith Morgan, Terence M. Williams, Dafydd Thomas, Kathryn Winter.
Glycogen Synthase Kinase 3 beta (GSK3beta) is a prognostic biomarker in adenocarcinoma of the pancreas.

Zhang Q, Bhojani MS, Ben-Josef E , Sun Y, and Morgan MA.
Glycogen Synthase Kinase 3? in Pancreatic Cancer and its Implications in Chemotherapy and Radiation Therapy.

Lund G., Grembecka J and Cierpicki T.
Fragment screening identifies hot spot for CDC25B - CDK2/CyclinA protein-protein interaction - in preparation for Journal of American Chemical Society.

Lund G. Grembecka J and Cierpicki T.
Identification and evaluation of biological activity of novel inhibitor targeting CDK2-CDC25B interaction.
Human hepatocellular carcinoma stem cell expansion is promoted by tumor-associated macrophage secreted IL-6 and STAT3 signaling


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