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Cutaneous Lymphoma

Definition

Cutaneous Lymphoma sometimes referred to as Mycosis fungoides and/or the Sézary syndrome are diseases in which lymphocytes (a type of white blood cell) become cancerous and affect the skin.

Getting Diagnosed / Treatment

Cutaneous Lymphoma is treated at the U-M Cancer Center in the Cutaneous Lymphoma Clinic.

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How does Cutaneous Lymphoma Occur?

As noted, Mycosis fungoides and the Sézary syndrome are diseases in which lymphocytes become cancerous and affect the skin.

Lymphocytes are made in the bone marrow and fight infection and disease. There are three types of lymphocytes:

  • B-cell lymphocytes that make antibodies to help fight infection.
  • T-cell lymphocytes that help B-lymphocytes make the antibodies that help fight infection.
  • Natural killer cells that attack cancer cells and viruses.

In mycosis fungoides, T-cell lymphocytes become cancerous and affect the skin. In the Sézary syndrome, cancerous T-cell lymphocytes affect the skin and the peripheral blood.

Mycosis fungoides and the Sézary syndrome are types of cutaneous T-cell lymphoma. A possible sign of mycosis fungoides and the Sézary syndrome is a red rash on the skin.

Mycosis fungoides and the Sézary syndrome may move through the following phases:

  • Premycotic phase: A scaly, red rash in areas of the body that usually are not exposed to the sun. This rash does not cause symptoms and may last for months or years. It is hard to diagnose the rash as mycosis fungoides during this phase.
  • Patch phase: Thin, reddened, eczema-like rash.
  • Plaque phase: Thickened, red patches or reddened skin.
  • Tumor phase: Tumors form on the skin. These tumors may develop ulcers and the skin may get infected.

Additional Resource from the National Cancer Institute Get more information about this form of lymphoma on the Nactional Cancer Institute's General Information About Mycosis Fungoides and the Sézary Syndrome webpage.

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University of Michigan Comprehensive Cancer Center
1500 East Medical Center Drive
Ann Arbor, MI 48109

This site is part of the U-M Health System. The information presented is not a tool for self diagnosis or a substitute for professional care. © 2008 U-M Comprehensive Cancer Center